Friday, June 15, 2007

Mangosteen & Cancer

Independent Research From Across the World Regarding Mangosteen’s Impact on Cancer.

Antiproliferation, antioxidation and induction of apoptosis by
Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004

Jan;90(1):161-6. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.Department of
Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand.

These investigators found that an extract from the pericarp of the mangosteen fruit (major component in XanGo)
inhibited the growth of breast cancer cells. They also showed that the extract had potent antioxidant and cancer
cell death properties. They concluded that the extract from the pericarp of the mangosteen fruit has potential for chemoprevention.
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.

Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan.

These authors examined the effects of six xanthones extracted from the pericarps of the mangosteen fruit,
Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin (a xanthone) showed the most potent ability to cause the cancer cells death.
Garcinone E, a xanthone derivative, has potent cytotoxic effect against the
patocellular carcinoma cell lines.

Planta Med. 2002 Nov;68(11):975-9. Ho CK, Huang YL, Chen CC. Department of Medical Research &am p; Education, Veterans General Hospital, Taipei, ROC.

Investigators extracted and purified 6 xanthone compounds from the rinds (peel) of the fruit of Garcinia mangostana, mangosteen fruit. The investigators tested this extract on 14 different human liver cancer cell lines. Several chemotherapeutic agents (drugs) were included in the study for comparison. The results showed that one of the
xanthone derivatives which could be identified as “garcinone E” has potent cytotoxic effect (kill cells) on all liver
cancer cell lines as well as on the other gastric and lung cancer cell lines included in the screen. The
investigators suggested that “garcinone E” may be potentially useful for the treatment of certain types of cancer.
Alpha-mangostin induces Ca(2+)-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells.

J Pharmacol Sci. 2004 May;95(1):33-40. Sato A, Fujiwara H, Oku H, Ishiguro K, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

The researchers investigated the cell death effects of eight xanthones on pheochromocytoma (cancer) cells. Among these compounds, alpha-mangostin, from the fruit hull of Garcinia mangostana L. (mangosteen fruit), had the most potent effect with apoptosis (death) of these cells.
Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.

Bioorg Med Chem. 2002 Dec;10(12):3725-30. Pedro M, Cerqueira F, Sousa ME, Nascimento MS, Pinto M. Centro de Estudos de Quimica Organica, Fitoquimica e Farmacologia da Universidade do Porto, Faculdade de Farmacia, Porto, Portugal.

Twenty-seven xanthones were assessed for their capacity to inhibit the in vitro the growth of three human cancer cell lines, (breast cancer, renal cancer, melanoma). Inhibition of growth of these cancer cell lines depended on the type of xanthone used in the study.
Xanthone derivatives as potential anti-cancer drugs.

J Pharm Pharmacol. 1996 May;48(5):539-44. Lin CN, Liou SJ, Lee TH, Chuang YC, Won SJ. School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.

Researchers showed xanthone derived compounds to have potent anti- tumor activities against human cancer cells.
Gamma-pyrone compounds as potential anti-cancer drugs.

J Pharm Pharmacol. 1993 Sep;45(9):791-4. Liou SS, Shieh WL, Cheng TH, Won SJ, Lin CN. Natural Products
Research Center, Kaohsiung Medical College, Taiwan, Republic of China.

Researchers studied several compounds and found xanthones with enhanced anti-tumor activity against human cancer cell lines.

The “21-Day Challenge”

Mangosteen Juice in facing the challenge of cancer.

A) Drink 1 whole bottle of juice (about 25 oz.) PER DAY X 21 days
B) PLUS about a gallon water, such as DISTILLED water.
The “21-Day Challenge” proposes that individuals who have critical health issues—such as just about any form of cancer—issue a challenge to their health condition by committing themselves to drink an entire 25 oz. bottle of Mangosteen juice each day for a period of 21 days, **PLUS** drinking at least one gallon (eight 16 oz. glasses) of pure water—such as spring water—along with the juice. The 4 to 6 hour half-life of Mangosteen juice in the body would suggest that the consumption of both juice and water be spread out somewhat evenly throughout the 24 hours.

This is important in order to flush the toxins from the body. He did say the only
uncomfortable thing about it all was the need to stay very near a bathroom at all times!

**NOTE: It is essential that the recommended amount of water be consumed along with the juice. As the Mangosteen juice is consumed, the cells begin to function normally to clear and release toxins into the blood stream—and these toxins must be eliminated from the body. The rule of thumb for water consumption is 1/2 ounce for every pound of body weight for those who are sedentary, or 2/3 ounce for every pound of body weight for those who are active. For example, if you weight 100 pounds and are not active you would drink 50 ounces of water.

To make sure you are drinking all the water you need, find a large pitcher and fill it in the morning, making sure to consume all of the water before evening (refilled as necessary). Otherwise, you will think you’ve had enough water, but in fact, that is seldom the case!

(If you are unable to drink the required water, it is better to use less Mangosteen juice)

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